✦ LIBER ✦

Proton and Carbon Chemical Shift Assignment and Solution-State Conformation of the Macrocyclic Ring in the Macrolide Antibiotic Tylosin in Aprotic Solvents

✍ Scribed by Svetlana Simova; Galya Ivanova

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 415 KB
Volume: 34
Category: Article
ISSN: 0749-1581
DOI: 10.1002/(sici)1097-458x(199604)34:4<255::aid-omr878>3.0.co;2-w

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✦ Synopsis

The 'H and "C NMR spectra of the 16-membered macrolide antibiotic tylosin were unambiguously assigned. The solution conformation of the macrocyclic ring in aprotic solvents was investigated by a combination of NMR methods and force field calculations. The predominance of the conformer corresponding to the x-ray structure in aprotic solvents is proposed.