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Protocol for the MPTP mouse model of Parkinson's disease

✍ Scribed by Jackson-Lewis, Vernice; Przedborski, Serge


Book ID
109945955
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
295 KB
Volume
2
Category
Article
ISSN
1750-2799

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o