Biochemical alterations of the striatum in an MPTP-treated mouse model of Parkinson’s disease
✍ Scribed by Hayato Kuroiwa; Hironori Yokoyama; Hiroki Kimoto; Hiroyuki Kato; Tsutomu Araki
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 168 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-7490
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o
## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial