Cerebral alterations in a MPTP-mouse model of Parkinson’s disease – an immunocytochemical study
✍ Scribed by Y. Muramatsu; R. Kurosaki; H. Watanabe; M. Michimata; M. Matsubara; Y. Imai; T. Araki
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 770 KB
- Volume
- 110
- Category
- Article
- ISSN
- 1435-1463
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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o
## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial