Proteins Expressed by the c-myc Oncogene in Lymphomas of Human and Avian Origin
β Scribed by Eisenman, R. N.; Hann, S. R.
- Book ID
- 120142100
- Publisher
- The Royal Society
- Year
- 1985
- Tongue
- English
- Weight
- 447 KB
- Volume
- 226
- Category
- Article
- ISSN
- 0080-4649
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## Abstract Total cellular polyadenylated RNA from a variety of fresh human lymphoma and leukemia cells, characterized by histopathology and certain cell surface markers, was analyzed for the expression of three distinct cellular oncogenes (__cβoncgenes__), __cβerbB, cβmyc__ and __cβmyb__ by dotblo
Chromosome translocations involving 8q24, the band to which c-myc has been mapped (Dalla-Favera et a/., 1982). are a uniform finding in Burkitt's lymphoma (Bernheim et a/., 1981). However, in only a minority of the tumors is the rearrangement of the cmyc locus sufficiently close to the gene to be de