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Protein–protein interactions as targets for small molecule drug discovery

✍ Scribed by David C. Fry

Publisher
Wiley (John Wiley & Sons)
Year
2006
Tongue
English
Weight
713 KB
Volume
84
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Protein–protein interactions represent a highly populated class of targets for drug discovery. However, such systems present a number of unique challenges. This review presents an analysis of individual protein‐protein interaction systems which have recently yielded success in discovering drug‐like inhibitors. The structural characteristics of the protein binding sites and the attributes of the small molecule ligands are focused upon, in an attempt to derive commonly shared principles that may be of general usefulness in future drug discovery efforts within this target class. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 535–552, 2006

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

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