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ChemInform Abstract: Discovery of Small Molecule Inhibitors of Protein—Protein Interactions Using Combined Ligand and Target Score Normalization.

✍ Scribed by Fergal P. Casey; Emilie Pihan; Denis C. Shields

Publisher
John Wiley and Sons
Year
2010
Weight
15 KB
Volume
41
Category
Article
ISSN
0931-7597

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## Abstract As the ultimate function of proteins depends to a great extent on their binding partners, protein–protein interactions (PPIs) represent a treasure trove of possible new therapeutic targets. Unfortunately, interfaces involved in PPIs are not well‐suited for effective small molecule bindi