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Immunosuppressive Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein–Protein Interactions

✍ Scribed by Tim Geppert; Stefanie Bauer; Dr. Jan A. Hiss; Elea Conrad; Michael Reutlinger; Dr. Petra Schneider; Dr. Martin Weisel; Bernhard Pfeiffer; Prof. Dr. Karl-Heinz Altmann; Priv.-Doz. Dr. Zoe Waibler; Prof. Dr. Gisbert Schneider

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 583 KB
Volume: 51
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.201105901

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## Abstract Protein kinase CK2, a member of the serine/threonine kinase family, is an attractive therapeutic target for anticancer combination therapy. A multiple structure‐based modeling approach complemented with shape components was taken to build a reliable pharmacophore model for ATP‐competiti