## Abstract In cells, proteins execute specific tasks in crowded environments; these environments influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an inorganic cavity as in biosensors or biocatalysts, confinement or excluded volume plays an important role in
โฆ LIBER โฆ
Protein Stability and Macromolecular Crowding
โ Scribed by Sarkar, Mohona; Monteith, William B.; Wang, Yaqiang; Pielak, Gary J.
- Book ID
- 119209588
- Publisher
- Biophysical Society
- Year
- 2012
- Tongue
- English
- Weight
- 39 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0006-3495
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The concept of excluded volume and possible effects of excluded volume on the reactivity of macromolecules in highly volume-occupied or "crowded" media are introduced and briefly summarized. Theoretical and experimental studies of the effect of crowding on protein folding and unfolding, and on the e