✦ LIBER ✦

Influence of macromolecular crowding upon the stability and state of association of proteins: Predictions and observations

✍ Scribed by Allen P. Minton

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 133 KB
Volume: 94
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20417

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✦ Synopsis

The concept of excluded volume and possible effects of excluded volume on the reactivity of macromolecules in highly volume-occupied or "crowded" media are introduced and briefly summarized. Theoretical and experimental studies of the effect of crowding on protein folding and unfolding, and on the effect of crowding on protein association and aggregation, are reviewed. Possible effects of the effect of crowding on an initially native protein that can undergo unfolding, self-association of native protein, and/or aggregation of non-native protein are considered.

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