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Protein sequencing: Thermal conversion of thiazolinone derivatives of amino acids to thiohydantoins

✍ Scribed by Ruth L. Guyer; Charles W. Todd

Book ID: 102627284
Publisher: Elsevier Science
Year: 1975
Tongue: English
Weight: 343 KB
Volume: 66
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(75)90607-7

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✦ Synopsis

A method for converting thiazolinone derivatives of amino acids to their thiohydantoin derivatives is described. Because this method proceeds through a thermally induced intramolecular rearrangement, the amide groups of glutamine and asparagine are not hydrolyzed. Special procedures are not required for the recovery of the derivatives of arginine and histidine. Finally, the thermal method is more rapid than the conventional aqueous conversion procedure.

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