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Protein Secretion Pathways in Bacteria

✍ Scribed by Joen Luirink, Bauke Oudega (auth.), Bauke Oudega (eds.)


Publisher
Springer Netherlands
Year
2003
Tongue
English
Leaves
294
Edition
1
Category
Library

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✦ Synopsis


For bacteria ..."the times are achanging"... The genomes of over 60 different bacteria have now been sequenced, and we know a lot about the important research organism Escherichia coli, the important industrial organism Bacillus subtilis, and about important plant and human pathogens. It will not take long before we know all the gene products and their functions of a few of these bacteria. Some of us already begin to think about a digital model E. coli or Bacillus cell. For that end we need to know all the physiological activities and metabolic routes of the cell. But in addition we like to know how things work at the molecular level and how protein and membranes as well as other (macromolecular) structures work together to carry out specific cell functions.

Protein Secretion Pathways in Bacteria describes all the known folding and targeting routes of inner and outer membrane proteins as well as of proteins that are secreted by several specific export routes. The book gives detailed molecular information about the structures that are important for the different mechanisms involved. This is a valuable contribution to the understanding of how rather simple and yet complex bacterial cells work.

✦ Table of Contents


Front Matter....Pages i-vii
Protein Targeting to the Inner Membrane....Pages 1-21
The Sec Translocase....Pages 23-49
The Tat Protein Export Pathway....Pages 51-64
Assembly of Inner Membrane Proteins in Escherichia Coli ....Pages 65-82
Biogenesis of Outer Membrane Proteins....Pages 83-97
Chaperones and Folding Catalysts Involved in the General Protein Secretion Pathway of Escherichia Coli ....Pages 99-119
Type I Protein Secretion Systems in Gram-Negative Bacteria: Escherichia Coli Ξ±-Hemolysin Secretion....Pages 121-139
Type II Protein Secretion....Pages 141-165
The Type III Secretion Pathway in Pathogenic Bacteria....Pages 167-190
Autotransporters....Pages 191-205
Assembly of Adhesive Organelles on Gram-Negative Bacteria....Pages 207-232
Export of Bacteriocins....Pages 233-247
Biogenesis of Flagella: Export of Flagellar Proteins via the Flagellar Machine....Pages 249-270
Protein Secretion in Gram-Positive Bacteria....Pages 271-296

✦ Subjects


Microbiology; Infectious Diseases; Biochemistry, general


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