Bacterial Type III Protein Secretion Systems

✍ Scribed by Samuel Wagner, Jorge E. Galan

Publisher: Springer International Publishing;Springer
Year: 2020
Tongue: English
Leaves: 234
Series: Current Topics in Microbiology and Immunology 427
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen’s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs.

This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly.

Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.

✦ Table of Contents

Front Matter ....Pages i-viii
A Unified Nomenclature for Injectisome-Type Type III Secretion Systems (Samuel Wagner, Andreas Diepold)....Pages 1-10
Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion (Marcel Volk, Ines Vollmer, Ann Kathrin Heroven, Petra Dersch)....Pages 11-33
Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System (Andreas Diepold)....Pages 35-66
The Structure of the Type III Secretion System Needle Complex (Sean Miletic, Nikolaus Goessweiner-Mohr, Thomas C. Marlovits)....Pages 67-90
Molecular Organization and Assembly of the Export Apparatus of Flagellar Type III Secretion Systems (Tohru Minamino, Akihiro Kawamoto, Miki Kinoshita, Keiichi Namba)....Pages 91-107
Structures of Type III Secretion System Needle Filaments (Birgit Habenstein, Nadia El Mammeri, James Tolchard, Gaëlle Lamon, Arpita Tawani, Mélanie Berbon et al.)....Pages 109-131
The Type III Secretion System Sorting Platform (María Lara-Tejero)....Pages 133-142
Export Mechanisms and Energy Transduction in Type-III Secretion Machines (Thibaud T. Renault, Alina Guse, Marc Erhardt)....Pages 143-159
Flagellar Hook/Needle Length Control and Secretion Control in Type III Secretion Systems (Shin-Ichi Aizawa)....Pages 161-172
The Tip Complex: From Host Cell Sensing to Translocon Formation (William D. Picking, Michael L. Barta)....Pages 173-199
Diversity and Evolution of Type III Secreted Effectors: A Case Study of Three Families (Donald Patrick Bastedo, Timothy Lo, Bradley Laflamme, Darrell Desveaux, David S. Guttman)....Pages 201-230

✦ Subjects

Biomedicine; Medical Microbiology; Infectious Diseases; Bacteriology

📜 SIMILAR VOLUMES

Bacterial protein secretion systems : me

📁 Bacterial protein secretion systems : methods and protocols

✍ Cascales, Eric; Journet, Laure 📂 Library 📅 2017 🏛 Humana Press ; Springer 🌐 English

This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complex

Protein Secretion in Bacteria

📁 Protein Secretion in Bacteria

✍ Maria Sandkvist; Eric Cascales; Peter J. Christie 📂 Library 📅 2019 🏛 ASM Press 🌐 English

Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial an

Protein Secretion Pathways in Bacteria

📁 Protein Secretion Pathways in Bacteria

✍ Joen Luirink, Bauke Oudega (auth.), Bauke Oudega (eds.) 📂 Library 📅 2003 🏛 Springer Netherlands 🌐 English

For bacteria ..."the times are achanging"... The genomes of over 60 different bacteria have now been sequenced, and we know a lot about the important research organism Escherichia coli, the important industrial organism Bacillus subtilis, and about important plant and human p

Protein Secretion and Export in Bacteria

📁 Protein Secretion and Export in Bacteria

✍ B. D. Davis (auth.), Henry C. Wu M.D. Ph.D, Phang C. Tai Ph.D (eds.) 📂 Library 📅 1986 🏛 Springer-Verlag Berlin Heidelberg 🌐 English

The last decade has witnessed rapid progress in our under standing of the mechanisms of protein export and secretion in both prokaryotic and eukaryotic cells. Studies of protein secretion across the membranes of the rough endoplasmic reticulum have led to the formulation of the now-classic signa

Immunobiology of Proteins and Peptides—I

📁 Immunobiology of Proteins and Peptides—III: Viral and Bacterial Antigens

✍ M. Zouhair Atassi (auth.), M. Zouhair Atassi, Howard L. Bachrach (eds.) 📂 Library 📅 1985 🏛 Springer US 🌐 English

This symposia series, founded in 1976, is devoted to the advancement and dissemination of knowledge in the field in immunology, particularly as it relates to the immune recognition and responses to protein and peptide antigens. Leading investigators are convened every 2 or 3 years for the purpose

Type IV Secretion in Gram-Negative and G

📁 Type IV Secretion in Gram-Negative and Gram-Positive Bacteria

✍ Steffen Backert, Elisabeth Grohmann 📂 Library 📅 2017 🏛 Springer International Publishing 🌐 English

Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural dive