Protein quality control in the early secretory pathway
โ Scribed by Anelli, Tiziana; Sitia, Roberto
- Book ID
- 110032344
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 275 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0261-4189
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๐ SIMILAR VOLUMES
Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg.
## Abstract Analysis of secretory proteins is an important area in proteomic research. We propose that a good secretory protein sample should be enriched with known secretory proteins, and a secretory protein should be enriched in the secretory protein sample compared with its corresponding soluble