Protein processing within the secretory pathway

✍ Scribed by Alnawaz Rehemtulla; Randal J. Kaufman

• Book ID: 103978429
• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 607 KB
• Volume: 3
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/0958-1669(92)90086-x

✦ Synopsis

Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg. The enzymes responsible for the processing belong to a newly discovered family of serine proteases related to the bacterial subtilisins. These include PACE (furin), PC1/PC3, PC2 and PACE4, which have all been characterized functionally and structurally.