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Protein Kinase C as a Component of a Nerve Growth Factor-Sensitive Phosphorylation System in PC12 Cells

✍ Scribed by Tokiko Hama, Kuo-Ping Huang and Gordon Guroff


Book ID
123632686
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
772 KB
Volume
83
Category
Article
ISSN
0027-8424

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Involvement of protein kinase C in nerve
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Both nerve growth factor (NGF) and K-252a stimulate the uptake of calcium into PC12 cells. Stimulation by either is prevented by pretreatment of the cells with the tumor promoter phorbol 12-myristate 13-acetate (PMA), suggesting an involvement of protein kinase C in the stimulation. The effect of PM