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Protein kinase C activity in human colonic adenoma and colorectal carcinoma

✍ Scribed by Masato Kusunoki; Youichirou Sakanoue; Takuya Hatada; Hidenori Yanagi; Takehira Yamamura; Joji Utsunomiya

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 628 KB
Volume: 69
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19920101)69:1<24::aid-cncr2820690107>3.0.co;2-1

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## Abstract Protein kinase C (PKC) activity was measured in normal‐appearing colonic mucosa from patients undergoing colonic resection. Comparisons were made between cases with and without colorectal cancers. PKC activity in cytosolic and particulate fractions was significantly reduced in patients