𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Protein kinase C activity as marker for colorectal cancer

✍ Scribed by Youichirou Sakanoue; Takuya Hatada; Masato Kusunoki; Hidenori Yanagi; Takehira Yamamura; Joji Utsunomiya

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
436 KB
Volume
48
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Protein kinase C (PKC) activity was measured in normal‐appearing colonic mucosa from patients undergoing colonic resection. Comparisons were made between cases with and without colorectal cancers. PKC activity in cytosolic and particulate fractions was significantly reduced in patients with colorectal cancer: 40 Β± 9 and 114 Β± 29 (pmol/min/mg) respectively, compared with patients without cancer; 129 Β± 11 and 250 Β± 38 (pmol/min/mg) (p < 0.05). Normal‐appearing colonic mucosa in patients with cancer showed significantly decreased total PKC activities in the cytosolic and particulate fractions compared with those In patients without cancer (10 Β± I and 20 Β± 3 vs. 30 Β± 2 and 33 Β± 6) (pmol/min/g tissue) (p < 0.05). The cellular distribution (% particulate fraction) of PKC activity in normal‐appearing mucosa in patients with cancer (64%) was higher than in patients without cancer (49%) (p < 0.05). Our data suggest that PKC activity may be used as a biological marker of risk of developing colorectal cancer or risk of bearing an asymptomatic tumor.

πŸ“œ SIMILAR VOLUMES

Metastasis-associated protein S100A4β€”a p
Metastasis-associated protein S100A4β€”a potential prognostic marker for colorectal cancer
✍ A.K. Hemandas; M. Salto-Tellez; S.H. Maricar; A.F.P.K. Leong; C.K. Leow πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 220 KB

Background and Objectives: Expression of S100A4, a small calcium-binding protein, in breast, oesophagus and gall bladder cancers is shown to be associated with adverse clinical outcome. We retrospectively examined the correlation of S100A4 expression and outcome in patients with colorectal cancer. M

Quantitative expression of protein marke
Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer
✍ Da-Qiang Seetoo; Philip J. Crowe; Pamela J. Russell; Jia-Lin Yang πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 391 KB

## Abstract ## Background and Objectives Certain pathophysiological markers may be helpful in selecting further therapies for patients with resected colorectal cancer (CRC). The aim of this study was to determine whether expression of proteins of the plasminogen activation system (PAS), which are