𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Protein backbone interaction with nucleic acid base pairs: A theoretical investigation

✍ Scribed by Ramakrishna V. Hosur; A. Pohorille

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
371 KB
Volume
20
Category
Article
ISSN
0020-7608

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A novel model of interaction between peptide backbone and nucleic acid base pairs, proposed earlier on the basis of model building studies has been theoretically investigated. Interaction energies for two different schemes of H‐bond interaction between peptide backbone and base pairs A____U and G____C have been calculated for different conformations of peptide backbone. The different H‐bond parameters have been calculated. The importance of such an interaction in specific recognition has been discussed in light of the results of theoretical calculations.

📜 SIMILAR VOLUMES

Protein–Nucleic acid interactions: Inves
Protein–Nucleic acid interactions: Investigations on the peptide backbone interaction with polynucleotides
✍ Ramakrishna V. Hosur; N. Vasanth Kumar; Girjesh Govil 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

## Abstract Model building, difference spectroscopy, and ^1^H and ^13^C NMR experiments have been carried out to study the binding of poly(L‐Ser) with the polyribonucleotides poly(__A__) and poly(__U__) at __p__H 7.1. Studies have also been carried out with base paired duplexes poly(__A__)ṁpoly(__U

Theoretical studies on protein–nucleic a
Theoretical studies on protein–nucleic acid interactions. III. Stacking of aromatic amino acids with bases and base pairs of nucleic acids
✍ N. Vasant Kumar; Girjesh Govil 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 658 KB

Stacking of aromatic amino acids tryptophan (Trp), tyrosine (Tyr), phenylalanine (Phe), and histidine (His) with bases and base pairs of nucleic acids has been studied. Stacking energies of the amino acid-base (or base pair) complexes have been calculated by second-order perturbation theory. Our res

Theoretical studies on protein–nucleic a
Theoretical studies on protein–nucleic acid interactions. II. Hydrogen bonding of amino acid side chains with bases and base pairs of nucleic acids
✍ N. Vasant Kumar; Girjesh Govil 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 601 KB

With a view to understanding the role of hydrogen bonds in the recognition of nucleic acids by proteins, hydrogen bonding between the bases and base pairs of nucleic acids and the amino acids (Am, Gln, Asp and Glu, and charged residues Arg+, Glu-, and Asp-) has been studied by a second-order perturb

Theoretical studies on protein–nucleic a
Theoretical studies on protein–nucleic acid interactions. I. Interaction of positively charged amino acids with nucleic acid fragments
✍ N. Vasant Kumar; Girjesh Govil 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 703 KB

Coulombic interactions between the side chains of charged amino acids (Arg + , Lys-, and H i s + ) and negatively charged phosphate groups of nucleic acid fragments have been studied theoretically. Diribose monophosphate and dideoxyribose monophosphate a r e chosen as model systems for single-strand