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Phosphono Peptide Nucleic Acids with a Constrained Hydroxyproline-Based Backbone

✍ Scribed by Vladimir A. Efimov; Valeryi N. Klykov; Oksana G. Chakhmakhcheva

Publisher
John Wiley and Sons
Year
2004
Weight
71 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract magnified image A novel peptide nucleic acid (PNA) monomer 16 containing a novel 1‐methyl‐6‐mercaptopurine base was synthesized by coupling the __in situ__ generated acid chloride of (1‐methyl‐6‐mercaptopurin‐9‐yl)acetic acid (6) into an L‐lysine backbone (13) using 10% CCl~4~ in pyrid