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Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats

✍ Scribed by Kouichi Ohta; Takanobu Kikuchi; Satoko Arai; Noriko Yoshida; Atsuko Sato; Nagahisa Yoshimura

Book ID: 116455867
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 348 KB
Volume: 77
Category: Article
ISSN: 0014-4835
DOI: 10.1016/j.exer.2003.08.014

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Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with ␤-amyloid peptide (␤-AP 1-40 ) or hydrogen peroxide (H 2 O 2 ), we detected high levels of reactive oxygen species, accompanied by a significant