Studies into the mechanism of acetaminophen (APAP)-induced hepatotoxicity have focused mainly at the hepatocellular level. This study aimed to investigate the effect of acetaminophen on the hepatic microvasculature using a vascular casting technique. Acetaminophen was administered at a dose of 650 m
Protective effect of deferoxamine for acetaminophen induced liver injury
โ Scribed by Sakaida, I. ;Kayano, K. ;Kubota, M. ;Mori, K. ;Takenaka, K. ;Yasunaga, M. ;Okita, K.
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 76 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0435-1339
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๐ SIMILAR VOLUMES
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses. We have previously found that the antirheumatic drug leflunomide is a potent inhibitor of APAP toxicity in cultured human hepatocytes, protecti
An increase in alpha-fetoprotein (AFP) following hepatic necrosis is considered indicative of hepatic regeneration. This study evaluated the prognostic value of serial AFP measurements in patients with severe acetaminophen-induced liver injury. Prospectively, serial measurements of AFP were performe