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Protection of NG108-15 Cells from P2X7 Receptor-Mediated Toxicity by Taurine

✍ Scribed by Leung, Yuk M.; Chao, Chia; Kuo, Chang; Huang, Chieh; Cheng, Tzu; Chan, Paul

Book ID
122924822
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
48 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract P2X7 receptor (P2X7R) activation by extracellular ATP triggers influx of Na^+^ and Ca^2+^, cytosolic Ca^2+^ overload and consequently cytotoxicity. Whether disturbances in endoplasmic reticulum (ER) Ca^2+^ homeostasis and ER stress are involved in P2X7R‐mediated cell death is unknown. I