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Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine

✍ Scribed by Chao, Chia-Chia; Chan, Paul; Kuo, Chang-Shin; Gong, Chi-Li; Cheng, Tzu-Hurng; Liu, Zhong-Min; Shen, Pei-Chen; Huang, Chieh-Chen; Leung, Yuk-Man

Book ID
122169854
Publisher
Elsevier
Year
2014
Tongue
English
Weight
875 KB
Volume
66
Category
Article
ISSN
1734-1140

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## Abstract P2X7 receptor (P2X7R) activation by extracellular ATP triggers influx of Na^+^ and Ca^2+^, cytosolic Ca^2+^ overload and consequently cytotoxicity. Whether disturbances in endoplasmic reticulum (ER) Ca^2+^ homeostasis and ER stress are involved in P2X7R‐mediated cell death is unknown. I