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Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

✍ Scribed by Stanislaw J. Czuczwar; Brian Meldrum

Book ID: 115877207
Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 256 KB
Volume: 83
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(82)90273-4

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There is now considerable evidence that the N-methyl-D-aspartic acid receptor is important in the genesis of seizures. One of the selective antagonist of the NMDA receptor is 2-amino-7-phosphonoheptanoic acid (APH). In this study we evaluated the effects of intracerebroventricular (i.c.v.) administr