Protected peptidep-nitroanilides by solid-phase synthesis
โ Scribed by Monika Mergler; Fritz Dick; Jacques Gosteli; Rolf Nyfeler
- Book ID
- 105576499
- Publisher
- Springer Netherlands
- Year
- 2000
- Tongue
- English
- Weight
- 501 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1573-3149
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A mild and efticient method to obtaia fully t-&tyl type protected alcohols based on the alkylation of Fmoc amino alcohols with the "polymeric dipheayldiazomethane" 1 followed by StanQrd Fmoc solid phase synthesis is presented. The resulting pepidyl benzhydryl ethers 3 can he cleaved with 1 -2% trlfl
Boc/'Z-protected PNA oligomers were synthesised on solid phase. The use of the allylic HYCRON resin allowed for the application of both Boc-and Fmoc-protecting groups. Highest yields were obtained when the monomeric building block was synthesised on solid phase rather than loaded as preformed unit.