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Proteasome Involvement in the Repair of DNA Double-Strand Breaks

✍ Scribed by Nevan J. Krogan; Mandy H.Y. Lam; Jeffrey Fillingham; Michael-Christopher Keogh; Marinella Gebbia; Joyce Li; Nira Datta; Gerard Cagney; Stephen Buratowski; Andrew Emili; Jack F. Greenblatt


Book ID
116753728
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
527 KB
Volume
16
Category
Article
ISSN
1097-2765

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## Abstract Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th