Proteasome Involvement in the Repair of DNA Double-Strand Breaks
β Scribed by Nevan J. Krogan; Mandy H.Y. Lam; Jeffrey Fillingham; Michael-Christopher Keogh; Marinella Gebbia; Joyce Li; Nira Datta; Gerard Cagney; Stephen Buratowski; Andrew Emili; Jack F. Greenblatt
- Book ID
- 116753728
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 527 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1097-2765
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π SIMILAR VOLUMES
A model is described for the repair of induced double-strand breaks in DNA which involves a proposed heteroduplex intermediate and normally occurring repair enzymes. The model predicts that this repair can lead to non-reciprocal and/or reciprocal recombination. The evidence which has been evaluated
## Abstract Two mechanisms are available for the repair of DNA doubleβstrand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and nonβhomologous endβjoining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th