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The repair of double-strand breaks in DNA: A model involving recombination

✍ Scribed by Michael A. Resnick

Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
526 KB
Volume
59
Category
Article
ISSN
0022-5193

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✦ Synopsis

A model is described for the repair of induced double-strand breaks in DNA which involves a proposed heteroduplex intermediate and normally occurring repair enzymes. The model predicts that this repair can lead to non-reciprocal and/or reciprocal recombination. The evidence which has been evaluated from other studies indicates a clear correspondence between the production of double-strand breaks and the occurrence of intragenic recombinants. In addition, the model describes how enzymatic.allyinduced double-strand breaks could initiate recombination without concomitant loss of chromosomal segments.

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