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Protease-catalyzed incorporation of non-protein amino acids into peptides via the kinetically controlled approach

✍ Scribed by Toshifumi Miyazawa; Kazumi Hamahara; Mikiko Matsuoka; Yoshimi Shindo; Takashi Yamada


Book ID
110222869
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
144 KB
Volume
20
Category
Article
ISSN
0141-5492

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Resolution of non-protein amino acids vi
✍ Toshifumi Miyazawa; Hiroe Minowa; Toyoko Miyamoto; Kiwamu Imagawa; Ryoji Yanagih πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 232 KB

In the microbial protease-catalyzed hydrolysis of amino acid esters with the free cx-amino group, the enantioselectivity can be enhanced greatly by employing esters with longer alkyl chains such as the isobutyl ester instead of the conventional methyl ester and by conducting the reaction at low temp