Prostate-specific Membrane Antigen (PSMA)-specific Monoclonal Antibodies in the Treatment of Prostate and Other Cancers
β Scribed by Michael C. Gong; Sam S. Chang; Michel Sadelain; Neil H. Bander; Warren D.W. Heston
- Book ID
- 110234090
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 62 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0167-7659
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## Abstract Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an impo
## Background: Prostate-specific membrane antigen (psma) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide n-acetylaspartylglutamate (naag) and gamma-linked folate polyglutamate. the prostate enzyme has activity in both the membrane and cytoso
## Abstract Prostate specific membrane antigen (PSMA) is a folate Ξ³ glutamyl carboxypeptidase that is oriented on the plasma membrane of normal and prostate cancer cells. A cytosolic version of PSMA, PSMβ², results from alternative splicing of the PSMA gene. Two additional alternatively spliced vari