Heterogeneity of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Carcinoma with Distant Metastasis
โ Scribed by Sebastian Mannweiler; Peter Amersdorfer; Slave Trajanoski; Jonathan A. Terrett; David King; Gabor Mehes
- Book ID
- 107636267
- Publisher
- Springer Netherlands
- Year
- 2008
- Tongue
- English
- Weight
- 260 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1219-4956
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## Abstract Prostate specific membrane antigen (PSMA) is a folate ฮณ glutamyl carboxypeptidase that is oriented on the plasma membrane of normal and prostate cancer cells. A cytosolic version of PSMA, PSMโฒ, results from alternative splicing of the PSMA gene. Two additional alternatively spliced vari
## Background: Prostate-specific membrane antigen (psma) is a novel prostate biomarker overexpressed in poorly differentiated and metastatic prostate carcinomas and apparently upregulated following hormone-ablation therapy. psma appears to be a satisfactory target for antibody-directed imaging of p