## Background: Prostate-specific membrane antigen (psma) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide n-acetylaspartylglutamate (naag) and gamma-linked folate polyglutamate. the prostate enzyme has activity in both the membrane and cytoso
Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer
โ Scribed by Feneley, M R; Jan, H; Granowska, M; Mather, S J; Ellison, D; Glass, J; Coptcoat, M; Kirby, R S; Ogden, C; Oliver, R T D
- Book ID
- 110073189
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 368 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1365-7852
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## Abstract Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an impo
We will review the evolution, benefits, and limitations of PSMA testing in the past, as well as its current and future value. Prostate cancer has been the most frequently diagnosed cancer and the second leading cause of cancer death in men in the United States. It has a wide spectrum of biological b
## Abstract Prostate specific membrane antigen (PSMA) is a folate ฮณ glutamyl carboxypeptidase that is oriented on the plasma membrane of normal and prostate cancer cells. A cytosolic version of PSMA, PSMโฒ, results from alternative splicing of the PSMA gene. Two additional alternatively spliced vari