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Prostaglandin endoperoxides. 15. Asymmetric total synthesis of levuglandin E2

✍ Scribed by Salomon, Robert G.; Miller, Donald B.; Raychaudhuri, Swadesh R.; Avasthi, Kamlakar; Lal, Kasturi; Levison, Bruce S.


Book ID
126868923
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
415 KB
Volume
106
Category
Article
ISSN
0002-7863

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We wish to report the synthesis of prostaglandin E2 (PGE2, &) via conjugate addition of the vinyl cupratez, derived from trans-3(E)-(l-ethoxyethoxy)l-iodo-l-octene (3b), to 2-(6-carbomethoxy-~-2-hexenyl)-4(R)-(2-tetrahydropyranyloxy)-2-cyclopenten-l-one (s). We also describe herein a novel synthesis