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A triply convergent total synthesis of l(-)-prostaglandin E2

✍ Scribed by Donaldson, R. E.; Fuchs, P. L.

Book ID
126465099
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
378 KB
Volume
103
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES

Total synthesis of prostaglandins. V. A
Total synthesis of prostaglandins. V. A synthesis of (βˆ’)-prostaglandin E2 via a totally asymmetric process.
✍ J.B. Heather; Rattan Sood; Philip Price; George P. Peruzzotti; Sang.S. Lee; Hsu πŸ“‚ Article πŸ“… 1973 πŸ› Elsevier Science 🌐 French βš– 225 KB

We wish to report the synthesis of prostaglandin E2 (PGE2, &) via conjugate addition of the vinyl cupratez, derived from trans-3(E)-(l-ethoxyethoxy)l-iodo-l-octene (3b), to 2-(6-carbomethoxy-~-2-hexenyl)-4(R)-(2-tetrahydropyranyloxy)-2-cyclopenten-l-one (s). We also describe herein a novel synthesis