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Prostaglandin E2 Induced Polymerization of Human α-1-Antichymotrypsin and Suppressed Its Protease Inhibitory Activity: Implications for Alzheimer's Disease

✍ Scribed by Federico Licastro; Lizabeth Jane Davis; Steve Pedrini; Douglas Galasko; Eliezier Masliah

Book ID: 115582498
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 182 KB
Volume: 249
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1998.9103

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A common polymorphism in the α1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t