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Interleukin-1β induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease

✍ Scribed by J.J.M. Hoozemans; R. Veerhuis; I. Janssen; A.J.M. Rozemuller; P. Eikelenboom

Book ID
114253532
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
306 KB
Volume
36
Category
Article
ISSN
0531-5565

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the