Gender-specific nonrandom association between the α1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease
✍ Scribed by M. Ilyas Kamboh; Dharambir K. Sanghera; Christopher E. Aston; Clareann H. Bunker; Richard F. Hamman; Robert E. Ferrell; Steven T. DeKosky
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 51 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
A common polymorphism in the α1-antichymotrypsin (ACT) gene has been found to modify the APOE*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in two large population-based samples of Caucasians (n = 803) and Nigerian Blacks (n = 730). Significantly higher frequencies of the ACT*A (78.6% vs. 48.4%; P < 0.001) and APOE*4 (25.6% vs. 15.6%; P < 0.001) alleles were observed in Nigerian Blacks than in Caucasians. In Caucasian women but not in men, the frequency of the APOE*4 allele was significantly lower in the ACT/AA genotype as compared to the ACT/AT and ACT/TT genotypes, while a reverse trend was seen for the APOE*3 allele frequency among the ACT genotypes.