Single channel currents have been recorded from cultured adult human Schwann cells. In both cell-attached and -excised (inside-out) patches, openings from a high-conductance (360 pS) channel were observed; measurements of the zero-current potential indicated that the channel was predominantly select
Properties of Ion Channels in Cultured Adult Human Schwann Cells
โ Scribed by JAMES McLARNON; SEUNG KIM
- Book ID
- 119865476
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 167 KB
- Volume
- 633
- Category
- Article
- ISSN
- 0890-6564
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Cultured Schwann cells are characterized by a strong outward rectification of the membrane; the threshold of the outward currents is close to the resting membrane potential of about -50 mV (Gray et al.: In Ritchie, Keynes (eds): Ion Channels in Neural Membranes. New York: Alan R. Liss, Inc., pp 145-
In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative pote
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