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Voltage-Gated ion currents of schwann cells in cell culture models of human neurofibromatosis

✍ Scribed by Fieber, Lynne A.

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 112 KB
Volume: 300A
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.a.10312

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✦ Synopsis

Abstract

K^+^ (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor‐derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex. J. Exp. Zool. 300A:76–83, 2003. © 2003. Wiley‐Liss, Inc.

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