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K+ channel properties in cultured mouse Schwann cells: Dependence on extracellular K+

✍ Scribed by A. Verkhratsky; D. Hoppe; Dr. H. Kettenmann

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
493 KB
Volume
28
Category
Article
ISSN
0360-4012

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✦ Synopsis

In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the threshold of current activation was shifted to more negative potentials. This shift in the activation threshold was only observed with normal (50-60 mM) intracellular [K+] levels; it was not apparent when [K+]i was elevated to 145 mM. The control of [K+]o on the gating properties of K+ channels may serve to enhance the capability of the Schwann cell to take up [K+]o and thus may serve for [K+] homeostasis in the peripheral nerve.

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