Promoter hypermethylation ofKiSS-1gene in gastric cancer
โ Scribed by Zhi Yang; Dong-Qiu Dai; Yun-Yi Du
- Book ID
- 107467040
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2010
- Tongue
- English
- Weight
- 225 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1000-9604
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To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestina
## Abstract Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a precancerous lesion of the stomach, our study examines the presence of gene promoter hypermethylation in IM of p