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Detection of p16 promoter hypermethylation in serum of gastric cancer patients

✍ Scribed by Yasuaki Kanyama; Kenji Hibi; Hiroshi Nakayama; Yasuhiro Kodera; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Book ID
108582283
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
91 KB
Volume
94
Category
Article
ISSN
1347-9032

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## Abstract We previously proved that p16 promoter methylation present in the tumors of colorectal cancer patients can be detected in the serum of those same patients using methylation‐specific PCR (MSP). To seek the possibility that this technique could be applied to the monitoring of cancer recur

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## Abstract Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a precancerous lesion of the stomach, our study examines the presence of gene promoter hypermethylation in IM of p