Prolymphocytic leukemia treated with natural and recombinant α-interferon
✍ Scribed by Takeshi Terashima; Dr Ken-Ichi Ohtake; Tetsuhei Ogawa
- Book ID
- 101434800
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 235 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
The patient was a 65 year old woman with a massive splenomegaly and no lymphoadenopathy. An electron mlcroscopic study of the peripheral blood cells revealed that these cells were prolymphocytes with a single large nucleolus. Treatment with native and recombinant a-interferon has produced an impressive reduction in spleen size and in the count of prolymphocytes.
📜 SIMILAR VOLUMES
Two patients with chronic-phase chronic granulocytic leukemia initially responded to recombinant interferon a-2a (rlFN-a-2a) but relapsed as a result of development of hightiter neutralizing antibodies to rlFN-a-Sa. Both patients were subsequently treated with natural leukocyte IFN-(Y (IFN-a-n3), an
Ten patients with hairy cell leukemia (HCL) requiring therapy were treated with recombinant beta-serineinterferon (rIFN-Bser) (90 X lo6 units [Ul subcutaneously three times a week). Eight patients were evaluable for response and nine for toxicity. Five patients (63%) showed normalization of peripher