✦ LIBER ✦
Natural leukocyte interferon-α therapy in patients with chronic granulocytic leukemia who have antibody-mediated resistance to treatment with recombinant interferon-α
✍ Scribed by Tefferi, Ayalew; Grendahl, Darryl C.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 300 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
Two patients with chronic-phase chronic granulocytic leukemia initially responded to recombinant interferon a-2a (rlFN-a-2a) but relapsed as a result of development of hightiter neutralizing antibodies to rlFN-a-Sa. Both patients were subsequently treated with natural leukocyte IFN-(Y (IFN-a-n3), and one of the two patients achieved a durable second hematologic and cytogenetic remission. IFN-a-n3 may be considered for patients in whom antibody-mediated resistance to rlFN-a-2a develops.