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Neutralizing interferon β antibodies in melanoma patients treated with recombinant and natural interferon β

✍ Scribed by Gerhard Fierlbeck; Tilmann Schreiner; Bernd Schaber; Anton Walser; Gernot Rassner

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
558 KB
Volume
39
Category
Article
ISSN
0340-7004

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Background. Prolonged therapy with interferon (IFN) may lead to the formation of IFN antibodies. Methods. Patients with renal cell carcinoma (n = 270) with advanced localized disease were randomized after complete tumor resection to receive treatment with adjuvant recombinant IFN-alpha-2a (rIFN-a2a