Clinical phase II trial of recombinant dna interferon (interferon alfa 2b) in patients with metastatic malignant melanoma
β Scribed by Thierry Dorval; Thao Palangie; Michel Jouve; Emilio Garcia-Giralt; Lucien Israel; Ernesto Falcoff; Denis Schwab; Pierre Pouillart
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 381 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0008-543X
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## Background: Recombinant interferon-alpha (ifn) augments the cytotoxicity of both 5-fluorouracil (5-fu) and cisplatin in vitro. a phase ii study of 5-fu and ifn resulted in response rates of 25-27% in patients with metastatic esophageal carcinoma. ## Methods: A phase ii trial was initiated to d
The authors tested a biotherapy regimen involving recombinant interferon-β£-2a (rIFN-β£-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. ## METH
A Phase I1 clinical trial of the combination of 5-fluorouracil (5-FU) and recombinant alpha-2a-interferon (a-2a-IFN) was conducted in 44 patients. Patients had not received chemotherapy previously and had measurable metastatic gastric carcinoma. 5-FU was administered as a continuous infusion at a do