Proline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors
β Scribed by Enders, Dieter ;Gasperi, Tecla
- Book ID
- 120485966
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 316 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/b611265j
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π SIMILAR VOLUMES
A series of o3-bmmo-2(S)-azido acids with side-chain lengths ranging from 3-5 methylene units has been synthesized. These intermediates enable the facile synthesis of chiral non-natural amino acids containing virtually any nucleophile capable of substituting the o3-bromo group.
L-methionine is obtained in good yield and high e.e. by using the carboxylation of an enantiopurecr-lithiooxazolidinonepreparedby tin-lithiumexchange.The entire processfrom cs-stannyl oxazolidinonetakes 35-40mn,time which is compatiblewitb the use of 11C02in radioactive chemistry directedto PET imag