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Asymmetric carboxylation in the synthesis of l-methionine: a new tool for 11C chemistry

✍ Scribed by Fabien Jeanjean; Nathalie Perol; Jacques Goré; Guy Fournet

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
473 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

L-methionine is obtained in good yield and high e.e. by using the carboxylation of an enantiopurecr-lithiooxazolidinonepreparedby tin-lithiumexchange.The entire processfrom cs-stannyl oxazolidinonetakes 35-40mn,time which is compatiblewitb the use of 11C02in radioactive chemistry directedto PET imaging. @ 1997Published by EIsevierScience Ltd.

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