Proline-Catalyzed Diastereoselective Direct Aldol Reaction Between 4-Oxoazetidine-2-carbaldehydes and Ketones.
β Scribed by Benito Alcaide; Pedro Almendros; Amparo Luna; M. Rosario Torres
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 33 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The CoCl~2~/Lβproline (1:2) system was found to be an excellent catalyst for direct aldol reactions. Excellent yields (up to 93β%) and a significant improvement in diastereoselectivity (__anti__/__syn__ up to 45:1) as well as enantioselectivity (up to more than 99β% __ee__) compared wit