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Proline-Catalyzed, Asymmetric Mannich Reactions in the Synthesis of a DPP-IV Inhibitor

✍ Scribed by Janey, Jacob M.; Hsiao, Yi; Armstrong, Joseph D.


Book ID
126995374
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
52 KB
Volume
71
Category
Article
ISSN
0022-3263

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Asymmetric Synthesis of Polyfunctionaliz
✍ Dieter Enders; Dominik P. Göddertz; Christian Beceño; Gerhard Raabe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 2 views

## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan